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Some molecules, like gases, lipids, and water itself (which also utilizes water channels in the membrane called aquaporins), slip fairly easily through the cell membrane

PiperinePiperine is an alkaloid extracted from black pepper that has the unique ability to enhance the transdermal absorption of other substances, primarily through the following mechanisms: altering the skin barrier (stratum corneum), inhibiting drug metabolism, and increasing cell membrane fluidity

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271,272 These pathways can be manipulated using agonists/antagonists, as well as molecular adaptors such as miRNAs to alleviate inflammatory reactions