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It is possible to cause activation-induced cell death in MDSCs and their transformation into inflammatory macrophages by blocking their glutamine metabolism [84] (Fig

Akkermansia is thought to promote barrier degradation because it utilizes the mucus layer as an energy source ( Akkermansia , Bifidobacterium , and Lactobacillus are often found to be increased in PD and would, in other circumstances, be recognized as beneficial bacteria and are marketed as probiotics (Wang et al., 2025)

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