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Oxidative stress has been identified as having an important role in cerebrovascular disease and given increasing recognition of the overlap between vascular dementia and AD (mixed dementia) and the contribution of vascular changes to AD [93] investigating potential effects of cerebrovascular disease as a covariate would be an important direction for future studies

Despite the promising findings reported in preclinical studies, it is important to emphasize that the majority of the available evidence originates from animal models and cell culture experiments

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