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thus, alterations in gene transcription may not always affect GPx-1 protein and enzyme activity levels to the extent suggested by the magnitude of transcriptional changes

Thats because NAD coenzymes impact pathways in the body that modify aging, according to a 2021 UK study that included human and animal data

10.1007/s11596-018-1989-8 214 YuS.LiuF.WangC.ZhangJ.ZhuA.ZouL.et al (2018)

Specifically, the malate/aspartate shuttle proteins MDH2, -KG/malate carrier, and GOT2 were found to be hyperacetylated leading to suppression of the transport and oxidation of cytosolic NADH in mitochondria, which correlated with decreases in oxygen consumption and cardiac energetics (manifested by a reduction in phosphocreatine/ATP) (42, 47)