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Following LCMS/MS analysis, the PRM acquisition approach was adopted to collect data from every sample to measure target protein levels

Other pathways impacted by APOE4 in our study, including methylmalonyl metabolism, fatty acid oxidation, and sirtuin signaling in females and branched-chain amino acid catabolism and mitochondrial translation in males, also play important roles in energy metabolism through their direct involvement in fuel oxidation, metabolic signaling, or synthesis of electron transport chain proteins

Swisher SG , Roth JA, Komaki R, Hicks M, Ro J, Dreiling L, Yver AB, Stevens C, Putnam JB, Jr, Smythe WR, Vaporciyan AA, Walsh GL

As a conclusion, inflammation, and stress regularly induce insulin resistance by common mechanisms