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Glutathione S-transferases are a family of enzymes that facilitate glutathiones redox maintenance function by conjugating glutathione onto oxidative substrates, thereby masking their reactivity and enhancing their secretion (Townsend et al,

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Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis (Ursini and Maiorino, 2020)