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[29] Diagnosis [edit] An earlier diagnosis of IPF is a prerequisite for earlier treatment and, potentially, improvement of the long-term clinical outcome of this progressive and ultimately fatal disease

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Notably, Troche and coworkers (258) elegantly demonstrated that deletion of ZIP14 alters the metabolism of white adipose tissue (WAT), rendering it insulin insensitive and increases the expression of cytokines such as leptin and IL-6 by disinhibiting NK-kB and JAK2/STAT3 signaling pathways ( Figure 3A a, b)

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