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Exposing SW620/Ad300 cells to 10 M IPI-549 for more than 72 h did not cause a significant change in the expression of P-gp, and the subcellular localization of P-gp on the cellular membrane remained unchanged ( In vivo , IPI549 improved the anti-tumor efficacy of paclitaxel in tumor xenograft model of P-gp-overexpressing SW620/Ad300 colon cancer with a ratio of growth inhibition for tumor volume (IRV) = 74% and for tumor weight (IRW) = 72%, compared to 42% IRV and 37% IRW for the paclitaxel alone treatment ( 4 Alterations in EGFR Low expression of EGFR or its key low-affinity ligands, amphiregulin (AREG) and epiregulin (EREG) causes loss of target for anti-EGFR therapy in CRC (Seligmann et al., 2016)

Can I take a higher dose than recommended?+ We recommend following the dosage indicated on the packaging