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While oxidative stress through H2O2 treatment leads to an all-or-none response and cell death in a dose dependent manner, serum starvation causes low-amplitude pulses of nuclear FOXO and predominantly results in cell-cycle arrest suggesting that the dynamics of FOXO nuclear shuttling dictates different cellular outcomes

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Upon HGF binding, Met is internalized by clathrin-mediated endocytosis and recruited into peripheral early endosomes

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