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It stimulates pulsatile growth-hormone release from pituitary somatotrophs without significant effect on ACTH, cortisol or prolactin in published models the basis for its classification as a selective GHRP

The senolytic effects varied between inducers and cell lines, but we identified 38 fragments (with diverse warheads, including chloroacetamides, cyanoacrylamides, acrylamides, aldehydes or sulfonyl fluorides) that selectively killed senescent cells in at least one of the three senescent conditions analysed (Fig