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Infinite coordination polymer polydopamine nanocomposites dual-pathway Multistep induction of long-term hyperimmunity combined with photothermal-chemo synergistic therapy colorectal cancer

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These results not only position DJX-A-KM as a promising KRAS-targeted therapeutic candidate but also introduce a degrader design paradigm that integrates endogenous E3 ligase biology with dual covalent chemistry, significantly expanding the targeted protein degradation toolkit

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