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This is achieved through the intrinsic 'safety lock' mechanism encoded in the N-terminal region of the fibrinogen -chain 52 which prevents premature fibrin polymerisation in the absence of thrombin activation 53

Moreover, alternative strategies for increasing the in vivo availability of polyphenols through their delivery via, e.g., encapsulation into nanocarriers or similar strategies, could increase their experimental and subsequent clinical use for supporting peripheral nerve regeneration and preventing secondary impairment after peripheral nerve injury, such as neuropathic pain

(2014) 9:e100980

P Natl Acad Sci USA (2007) 104(30):1228893