glutathione peroxidase 4 a new player in neurodegeneration

glutathione peroxidase 4 a new player in neurodegeneration Oxytosis/Ferroptosis in Neurodegeneration: the Underlying

Name: glutathione peroxidase 4 a new player in neurodegeneration Oxytosis/Ferroptosis in Neurodegeneration: the Underlying
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Oxytosis Ferroptosis in Neurodegeneration: the Underlying Role of Master Regulator Glutathione Peroxidase 4 (GPX4) Molecular Neurobiology Springer Nature Link Molecular Medicine Reports The Role of Glutathione Peroxidase 1 in Health and Disease PMC The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity: Cell Reports

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J Phys Chem B 110:1570015707

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Importantly, the anti-tumor protection conferred by early ferroptotic cells depended on ATP-Purinergic Receptor P2X7 signaling, as blockade with oxidized-ATP abolished this effect, highlighting how DCs process and present tumor antigens via MHC complexes to activate T cells (41)