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In low-resource nations, iron, folate, vitamin A, and iodine are in scant supply and their deficiency during pregnancy can contribute to multiple adverse outcomes in the mother and newborn

Cureus 16 (2), e54855

TB-500 may be more useful for systemic inflammation control, circulation, and global recovery

Although cognitive outcomes (ADAS-Cog11 and DSST) did not achieve statistical significance within this brief treatment window, the imaging pharmacodynamics provided evidence of CNS penetration and on-target activity, representing an important translational milestone that now warrants longer treatment windows, biomarker-anchored endpoints, and more stringent gatekeeping against type I error