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They inflict pain, lead to functional impairment and disability, and generate a massive financial burden for families and society ( Ferroptosis was proposed as a novel form of cell death in 2012

59 HSC aging can be induced by various mechanisms

65 Existing evidence suggests that the rate of alcohol metabolism by ADH is inversely proportional to the risk of AUD development in carriers

Endothelial dysfunction and aging Aging may alter the structure and function of vascular components, such as the endothelium, intimas and smooth muscle cells, resulting in an increase in the risk of development of cardiovascular and cerebrovascular diseases, which are related to hypertension