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Nazha A, Kantarjian HM, Ravandi F, Xuelin H, Choi S, Garcia-Manero G, Jabbour E, Borthakur G, Kadia TM, Konopleva M, Cortes JE, Ferrajoli A, Kornblau SM, Andreeff M , Du M, Brand M, Faderl SH

The core of the prevailing theories on the etiology of AD is the amyloid cascade hypothesis

The most often and potent ones attracted are the insulin receptor substrates 1/2 (IRS1/2)although there are 6 found to date- (not to forget that Shc proteins, p60dok, Cbl, APS, and Gab-1 are also recruited to activated IRs)

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