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Daratumumab monotherapy for patients with intermediate-risk or high-risk smoldering multiple myeloma: a randomized, open-label, multicenter, phase 2 study (CENTAURUS)

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The research program demonstrated important safety characteristics of growth hormone fragments while highlighting the challenges of translating preclinical metabolic effects to human therapeutic applications

With age the animals developed type 2 diabetes, underlining the metabolic consequences of largely elevated GH combined with circulating IGF-I deficiency (34)