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Systems that generate and eliminate reactive oxygen species (ROS) play crucial roles in sustaining the intracellular redox balance, which is essential for mediating redox signaling and governing cellular activities

Several studies have suggested that sphingolipid metabolism as effectors or modulators of the p53 tumor suppressor pathway, particularly sphingomyelinase and sphingosine kinase I (SK1), which are directly regulated by p53, contributing to ceramide-induced senescence in cells (Dbaibo et al., 1998

[9] And while both supplement dosages were associated with higher glutathione levels at the end of the study compared to the beginning, the study lacked a control group