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Malignancy of pancreas or bowel

and D.B), sponsored research funding from Calico Life Sciences, the Mayo and Noaber Foundations, NIH National Institute of Aging (NIA) grants AG-26094 (to E.N.C.), AG58812 (to E.N.C.), CA233790 (to E.N.C.), AG13925 (to J.L.K.), AG057493 (to J.M.v.D.), AG016694 (to J.M.S.) and P01 AG051449 (to J.M.S)

the invention encompasses use of one or more NNMT inhibitors for muscular therapy comprising contacting one or more cells with one or more NNMT inhibitors