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Thus, modulating vitamin B6 levels or its related metabolic pathways may offer a selective therapeutic window to target cancer cells

Alexander A, Dwivedi S, Ajazuddin, Giri TK, Saraf S, Saraf S, et al

For instance, the CPT1A inhibitor Etomoxir has not been widely used in cancer clinical trials

And circ P4HB could regulate SLC7A11 by regulating miR-1184 to trigger GSH synthesis, which can protect lung cancer cells from erastin-induced ferroptosis, and promote tumor growth in vivo [163]