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Epinephrine and AICAR-induced PGC-1 mRNA expression is intact in skeletal muscle from rats fed a high-fat diet

Vander Haar et al., 2007) and DEPTOR (DEP-domain-containing mTOR-interacting protein) (Peterson et al., 2009) interact with the complex via binding to RAPTOR and mTOR, respectively, and were shown to act as endogenous inhibitors of mTORC1 kinase activity