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Pernicious Anaemia is Lifelong: If your deficiency is due to pernicious anaemia (lack of intrinsic factor), B12 injections will be lifelong, as the underlying absorption problem is permanent

A randomized controlled trial in 167 older adults (50 years) found two-year supplementation with vitamin B 12 (10 g/day), along with folic acid (200 g/day), vitamin B6 (10 mg/day), riboflavin (5 mg/day), and vitamin D (10 g/day), had no effect on bone mineral density (total hip, femoral neck, or lumbar spine) compared to the control group only receiving vitamin D (10 g/day ) (116)

"Intrinsic factor autoantibodies by luminescent immuno-precipitation system in patients with corpus atrophic gastritis"

Both injections are given into the muscle of the buttocks, a few minutes apart, by a healthcare professional