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Description

a prospective randomized double blind placebo-controlled clinical trial

Treatment strategies encompass gene therapy, the development of small molecule activators or mimics, and methods to enhance cysteine uptake

Because an oral 15-PGDH inhibitor has already passed Phase 1 safety testing in humans for age-related #muscle weakness, the authors are hopeful that clinical trials in joint disease will follow, potentially paving the way for #nonsurgical, cartilage-regenerating therapies that could delay or replace knee and hip replacements