lysosome glutathione (GSH) is synthesized in the cytoplasm by the action of Small-Molecule Ligands Targeting Lysosome-Shuttling Receptors

Small Molecule Ligands Targeting Lysosome Shuttling Receptors and the Emerging Landscape of Lysosome Targeting Chimeras Journal of Medicinal Chemistry Lysosomal rupture: An emerging switch for collective ferroptosis ScienceDirect Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation PMC Ferroptosis regulation in lysosome Lysosomal iron and cathepsin B contribute to ferroptotic cell death. Lysosomal cyst(e)ine can be mobilized to maintain glutathione synthesis and glutathione peroxidase 4 activity, thereby limiting lipid peroxidation.

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