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Collectively, these results demonstrate that targeting OXPHOS is a metabolic vulnerability in metastatic ER + BC, including endocrine-resistant tumours

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Pain in the shoulder, commonly reported by patients with PD 15 , 43 , may be the first symptom in 2-8% and may even precede the onset of motor symptoms 44

M2 macrophages, due to their relatively weak antioxidant defenses, undergo ferroptosis first, and the subsequent release of DAMPs and TNF- further promotes M1 polarization, rendering macrophages a factor in amplifying inflammation