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Ye L, Xu Y, Wang L, Zhang C, Hu P, Tong S, et al

Synaptic microRNAs coordinately regulate synaptic mRNAs: perturbation by chronic alcohol consumption

If you have one or two copies of the ApoE4 mutation you have about a 500% to 1,200% increased risk for developing Alzheimers disease respectively compared to those who do not have the mutation