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indeed, compared with wild-type mice, Nrf2-deficient diabetic rodents exhibited significantly greater retinal superoxide levels after 5 weeks of diabetic modeling (75)

When symptoms are present, they usually relate to the underlying condition causing the elevation rather than the high B12 itself

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In addition, more CD4 + T cells expressed interferon- and interleukin (IL)-2, and increased plasma levels of IL-6, macrophage inflammatory protein 1, IL-1, tumor necrosis factor-alpha and the soluble IL-1 receptor antagonist in the Long COVID patients [59, 62, 63, 67,68,69,70], indicating activation of M1 macrophages and T helper (Th)-1 phenotypes [33]