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The role of copper in Huntingtons disease (HD) goes beyond directly binding to mutant huntingtin (mHTT) and promoting its aggregation

Maatta, T., Tervo-Maatta, T., Taanila, A., Kaski, M

[PubMed: 11035258] 377

However, clinical trials to target these early ROS-dependent pathways have shown less promising results than those targeting AGE formation or PKC signaling