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J Mol Cell Biol 2020;12:31821

Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy

it heavily targets the gastrointestinal tract due to the high concentration of ACE2 receptors found on the surface of intestinal enterocytes

Of course, the flip side is that prolonged stimulation of growth signals needs careful oversight, since anything that speeds up cell growth can have risks too