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Disclosures: Elizabeth Williams: Nothing to Disclose, Regina Weber: Nothing to Disclose, Archita Desai: Nothing to Disclose, Raj Vuppalanchi: Nothing to Disclose 1984 UNLOCKING EPHX1-MEDIATED ALTERATIONS IN EICOSATRIENOIC ACID METABOLISM: NOVEL THERAPEUTIC TARGETS IN LIVER FIBROSIS Hiroko Ikenaga 1 Tsutomu Matsubara 1 Masaru Enomoto 1 Misako Sato-Matsubara 1 Le Thi Thanh Thuy 1 NINHQUOC DAT 1 Truong Huu Hoang 1 Ngo Vinh Hanh 1 Chiho Kadono 1 Hideki Fujii 1 Sawako Uchida-Kobayashi 1 Shogo Tanaka 1 Shoji Kubo 1 Takeaki Ishizawa 1 Daisuke Oikawa 1 Fuminori Tokunaga 1 Akihiro Tamori 1 Sergi Guix-Muntet 2 Jordi Gracia-Sancho 2 Frank Gonzalez 3 Kazuo Ikeda 1 Norifumi Kawada 1 , 1 Osaka Metropolitan University, 2 IDIBAPS, 3 National Cancer Institute Background: Chronic liver diseases cause liver fibrosis, which can lead to cirrhosis and cancer

There arent enough studies to assess the safety of Betnesol concerning pregnancy complications

Sukhorukov et al., 2021) (Figure 9)

Chronic oxidative stress in pulmonary tissue imposes selective pressure for the upregulation of antioxidant systems, allowing tumor cells to counteract ferroptosis-inducing conditions (77)