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Effects of ibudilast on MRI measures in the phase 2 SPRINT-MS study

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7.5 Future directions: metabolic regulation and precision therapies While microglia are well-established as central to brain immunity, recent findings reveal their mechanistic roles in synaptic plasticity via C1q/C3 complement-mediated pruning and TREM2-DAP12-dependent phagocytosis, directly regulating neuronal survival and circuit homeostasis