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PubMed , Nutrition Reviews , vol

Adaptive resistance is a complex process in which tumors actively remodel both their intrinsic properties and the microenvironment to evade immune attack under persistent immunotherapeutic pressure [92]

It is critical to recall that all of this data comes from preclinical models (rodent, porcine, in vitro) and limited case studies

16 As none of those mentioned above markers can solely determine the specific type of cell senescence, various methods and hallmarks are required to clarify the exact category of a senescent cell