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doi: 10.1038/nri3581 244 Moreira-TeixeiraLMayer-BarberKSherAOGarraA

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Notably, the clinical use of canakinumab, an anti-IL-1 agent, has shown significant promise, as it reduced the incidence of lung cancer in patients with atherosclerosis, providing a robust clinical validation of the critical role of NLRP3 and IL-1 in cancer pathophysiology (Ridker et al., 2017b)