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6,52 However, it is still unclear whether NLRP3 and NOD2, which respond to a range of pathogen-derived stimuli, 52,53 can be activated by direct binding to mycobacterial extracellular RNAs, although a recent study reported that dsRNA from Mtb cultures is able to induce caspase-1 activation in retinal pigment epithelium

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Interestingly, consistent with our findings, several epidemiological studies have reported that dietary pyridoxine significantly decreases the risk of PD 62,63,64