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2 Treating TCN1 polymorphisms requires very high levels of cobalamin in the bloodstream (748-7480 pmol/ L), which is met through oral or intramuscular supplementation of 0.5-1.0 mg of methylcobalamin or hydroxycobalamin once or twice weekly

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[28] found that NNMT knockdown significantly reduced the body weight, fat mass, and insulin level of female mice fed a Western diet (fat 47% kcal, carbohydrate 34% kcal), as did NNMT knockout

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