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10.1159/000522485 50 KongW.LiuX.ZhuH.ZhengS.YinG.YuP.et al (2024)

196 Due to its poor bioavailability, however, NAC must be administered in fairly high doses and requires a long treatment time in patients with severe APAP overdose, thereby increasing the risk of an anaphylactoid reaction (i.e., nonimmunologic anaphylaxis), fluid overload, and high fluid osmolarity