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Efficacy of coenzyme Q10 in patients with cardiac failure: a meta-analysis of clinical trials

In addition, genetic defects in folate metabolism and its transport can cause megaloblastic anemia and a variety of neurological disorders, including developmental delays, intellectual disability, seizures, and ataxia, underscoring the vital role of folate in brain development and function during both fetal and postnatal stages [28, 29]

Reduce if gastrointestinal symptoms remain severe after six or more weeks at a given dose level, if significant dehydration results from persistent vomiting or diarrhea, if heart rate increases beyond 15 beats per minute above baseline, or if the side effect burden is causing protocol abandonment

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