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Roughly 48 h after initial infection, Mtb leverages ESAT-6 secretion system 1 (ESX-1) to secrete virulence factors ESAT-6 and CFP-10 that mediates its escape from the phagosome to enter the cytosol of the macrophage where it can replicate more rapidly [37]

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46 ProTracer uses a dual Cre- and Dre-mediated genetic system, providing an unbiased approach for tracing the proliferation of hepatic cell populations