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Similarly, in high-fat dietinduced (HFD induced) pre-diabetic rats subjected to cardiac ischemiareperfusion injury, administration of the mitochondrial fusion promoter M1 (2 mg/kg), either alone or in combination with the Drp1 inhibitor Mdivi-1 (1.2 mg/kg), significantly reduced mitochondrial dynamics imbalance, ROS generation, swelling, and membrane depolarization, which collectively decreased infarct size and arrhythmias while improving left ventricular function [177]

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Discussion Although konzo was first described in 1938, the biological mechanisms that contribute to the development of this disease have remained elusive 23