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When we experience a stress response and the nervous system causes spikes in cAMP within the heart, thenprovided there is enough NOcGMP also increases to keep the system in balance 33 (see Figure 5)

A cold extreme on day d is identified if the T max anomaly falls below the 10th percentile of the T max anomaly distribution defined by all 5-day intervals from 19812010 centered on the calendar day