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The identification of rare monogenic disorders, named Neurodegeneration with Brain Iron Accumulation (NBIA) and characterized by severe iron accumulation in basal ganglia and extrapyramidal movement dysfunction (list in Table 1), has further provided evidence of how alterations in iron homeostasis are related to neurodegeneration [12, 13]

Additionally, resveratrol has been shown to induce apoptosis in cancer cells by caspase activation, upregulate p53 expression, decrease expression of anti-apoptotic proteins including BCl2 and induce expression of proapoptotic proteins including BAX expression [31]

FIGURE 5 Functional and pathway analysis of SAT1-Interacting genes After confirming the role of Sat1 in MIRI, to find the pathway involved in the regulation of Sat1 to MIRI, the CTD database was searched to identify genes that interact with Sat1, and their functions and signaling pathways were analyzed

Acetylcysteine's antioxidant properties can help to reduce inflammation and protect the eye from further damage