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A total of 112 simulations were performed to study the impact of seven zonation hypotheses across a spectrum of APAP doses

Instead, for class 12 (hydrolysis of amides, lactams and peptides), the collected metabolic reactions are more heterogeneous, which may partly explain the lower but acceptable performance of the corresponding model

Similar to other TOPO1i payloads like DXd and SN-38, ED04 is expected to possess adequate membrane permeability to facilitate a bystander effect, which is likely contributing to the encouraging efficacy observed in HER2-heterogeneous breast cancer populations

Typically 1-3 injections spaced 4-6 weeks apart