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The results on exacerbation outcomes over the 12-month study period showed that the efficacy of erdosteine did not differ between ICS users and non-users in the total RESTORE population (Table 1)

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The -opioid receptor agonist U50448H provides another example, as it inhibits NLRP3/ caspase-1-induced pyroptosis in this case by activating cholinergic anti-inflammatory pathways and promoting the polarization of alveolar macrophages to the M2 type [131]