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Parkinson's disease and alpha-synucleinopathies: from arising pathways to therapeutic challenge

It seems that the regeneration program initiated after the toxic insult via cuprizone proceeds in a highly controlled manner running sequences of tightly orchestrated events on molecular and cellular levels beginning with an activation of microglia and astrocytes as a response to the oligodendrocyte insult within the first 3 weeks of cuprizone feeding followed by a massive proliferation of all glial cells and myelin clearance between the third and fifth week, and onset of remyelination around week 5.5 (Figures 3, 4)

10.1007/s12185-018-2411-9 173