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They were removed because the original nominators withdrew their nominations, which allowed the FDA to refer them to the Pharmacy Compounding Advisory Committee (PCAC) for formal review

Akar, S., et al

For this reason, we stated in the proposed rule that we believe requiring hospitals to include NPIs that meet our proposed criteria would not pose a significant burden or, for most hospitals, significantly increase the amount of data stored in the MRFs

It inhibits the activation of the transcription factor NF-B, reducing the production of pro-inflammatory cytokines (IL-1, TNF-, IL-6) and inflammatory mediators (PGE2, NO)