fsp1 is a glutathione-independent ferroptosis suppressor. Upregulation of CoQ shifts dependence from GPX4 to in acquired radioresistance Unleashing Ferroptosis in Human Cancers:

Cell Death Differ 29:10941106 Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman SC, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN (2018) Electrophilic properties of itaconate and derivatives regulate the ikappabzeta-atf3 inflammatory axis

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Clinical protocols for switching specifically to CagriSema will likely be established after the treatment receives approval and enters clinical practice