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Among those 22 protein complexes, we selected four, encompassing 11 of the 39 enzyme targets, for further experimental validation based upon additional criteria such as evidence from CRISPR-Cas9 screens 32,33,34 , relevance in other viral diseases, and the availability of inhibitors, as discussed below

Acknowledgments The authors acknowledge the support of the Department of Veterinary Clinical Sciences (VCS) Core Lab, College of Veterinary Medicine, Iowa State University

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6df, GPX4 protein levels were also decreased after treatment with heme, FAC, and erastin in the HNPCs, indicating that all three of these treatments can induce intracellular ROS production and cell death