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PMID: 33004292

Adult conditional knockout of PGC-1 leads to loss of dopamine neurons

One study found that in high glucose conditions, E2 dose-dependently increased lactate and glucose-6-phosphate (G6P) production in human MCF-7 breast cancer cells, whereas in low glucose conditions, E2 dose-dependently reduced lactate production and enhanced TCA cycle flux (201)

Studies on sepsis mouse models have shown that up-regulation of PD-L1 can inhibit the activity of caspase-3 and up-regulate the expression of Mcl-1 through the PD-1/PI3K/Akt signaling pathway, thereby delaying neutrophil apoptosis, leading to their abnormal accumulation in the lungs and exacerbating lung injury (42)