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Heatmap and PCA were generated by MetaboAnalyst ( Significance was determined using 1-way or 2-way ANOVA with Tukeys post hoc correction for multiple-variable experiments

Here we find increased proportion of pro-inflammatory and mesenchymal fibroblast subpopulations and senescent fibroblasts, and enhanced expression of senescence-associated secretory phenotype genes using single-cell RNA sequencing analysis, as well as elevated p16 protein and more -galactosidase-positive cells in keloids

It is recommended to lather the soap on damp skin and gently massage it in circular motions, allowing the active ingredients to penetrate the skin