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Why combining them creates a synergistic advantage The case for combining AOD 9604 with tirzepatide comes down to one principle: they target completely non-overlapping biological pathways

AOD-9604 works by activating the pituitary gland to promote lipolysis, the breakdown of stored fat, while simultaneously suppressing lipogenesis, the creation of new fat

This delivers approximately 0.2 mg of semaglutide, well below the therapeutic threshold but enough to begin receptor sensitization and assess initial tolerance

Paraesthesia, balance problems, or cognitive difficulties may persist despite normalising blood counts